Today, that vision, combined with the collective expertise and experience of our fertility specialists and support staff, has earned Newlife IVF recognition as one of Victoria’s top-performing IVF clinics.
According to the latest figures reported by the Herald Sun (sourced from the Federal Government’s Your IVF Success website), Newlife IVF holds the highest IVF success rate in Victoria for women under 35, with an impressive 62.5% of embryo transfers resulting in live birth.
For women aged 35 to 42, Newlife IVF also leads with the highest birth rates per embryo transfer in Metropolitan Melbourne (31.7%), placing us third overall in Victoria for this age group.
‘We are delighted to share that we have had another great year for our patients, with our pregnancy and birth success rates consistently above the national average. Our fertility specialist team focuses on providing the best possible milieu for eggs to mature and embryos to implant, and our amazing embryologists focus on every aspect of the egg, sperm and embryo care to provide a nurturing environment to achieve their developmental potential,’ said Dr Nicole Hope, fertility specialist and Medical Director at Newlife IVF.
A vision for exceptional fertility care
As a clinician-owned and led fertility clinic, we’re proud to be one of the few independent specialist fertility centres in Victoria. This independence allows us to offer a more personalised, supportive experience than corporate-owned clinics.
‘We feel so privileged to play a part in our patients’ journeys. Being able to provide a level of care that helps them achieve their dream of starting a family is truly an honour for us,’ said Dr Tiki Osianlis, Newlife IVF’s Managing Director and Scientific Director.
Every aspect of our practice is designed with our patients’ needs in mind. From our state-of-the-art laboratory to our use of advanced scientific tools and techniques, we combine expert-led care with cutting-edge science to give our patients the best possible chance of building the family they dream of.
‘Our IVF success rates highlight how effective our approach is. It’s not just about the science – it’s about the people. The entire team, from our fertility specialists and nurses to our embryologists, counsellors and admin staff, take the time to truly understand each patient’s unique journey. We adapt our care to fit their needs, and every single one of us is genuinely invested in helping our patients achieve their dream of becoming parents,’ said Dr Tiki.
Giving you Newlife in a different way
At Newlife IVF, we believe that everyone deserves the opportunity to build their family, which is why we’re committed to making high-quality fertility treatment as accessible as possible. We remain committed to delivering outstanding results and compassionate care, empowering our patients with the best possible chance of success.
If you’re ready to explore your options for having a baby, you can make an appointment with one of our specialists by calling (03) 8080 8933 or by booking online.
IVF is an assisted reproductive technique that helps people overcome fertility challenges to start or grow their families. This process involves fertilising an egg with sperm in a specialised laboratory, with the resulting embryo carefully transferred into the uterus with the aim that it will lead to a pregnancy.
Whether you’re just beginning your fertility journey or considering your options, understanding the IVF process is an empowering first step. In this article, we’ll guide you through the process that we use at our fertility clinic in Melbourne, to help you make informed decisions about your next steps.
A step-by-step guide to the IVF process at Newlife IVF in Melbourne
From the initial consultation through to the embryo transfer procedure, IVF involves a series of carefully coordinated stages – tailored to your unique needs – that are designed to give you the best chance of pregnancy success.
Initial consultation with our Melbourne-based fertility specialist
If you’re concerned about your fertility and would like to seek advice from a fertility specialist, you will need a referral from your GP to attend our IVF clinic.
During your initial consultation, your fertility specialist will assess your health and the factors contributing to your fertility issues, as well as provide tailored advice, including recommendations about diet and lifestyle. This process involves taking a thorough medical history from you, performing relevant examinations and ordering appropriate tests. Your fertility specialist will also discuss all available treatment options with you so you can make an informed decision about whether the IVF process is right for you.
If it is decided that IVF treatment is appropriate, we will register you as a patient at our fertility clinic. At this stage, mandatory tests, such as screening for infectious diseases, will be conducted if they have not been done previously.
Personalised fertility treatment planning
As no two fertility journeys are the same, fertility care at our IVF clinic in Melbourne is never one-size-fits-all. Our approach begins with uncovering the root causes of your fertility challenges and guiding you through the treatment options that best suit your unique circumstances. These options can range from straightforward solutions like fertility optimisation and ovulation induction to advanced treatments, such as intrauterine insemination (IUI), IVF, or IVF with intracytoplasmic sperm injection (ICSI).
Ovulation induction and hormone stimulation
Ovulation induction is a commonly used fertility treatment for individuals with ovulatory dysfunction. Often serving as an early intervention, it can be effective as a standalone treatment or combined with others, such as IUI or IVF, to improve the chances of conception. Ovulation induction involves using fertility medication to stimulate your ovaries to produce one or more mature eggs and assist with ovulation. For those undergoing IVF, hormone stimulation with fertility medications is used to stimulate your ovaries to produce a higher number of mature eggs than they normally would. This is a critical step in preparation for egg retrieval.
During this stimulation phase, self-administered hormonal injections are given over 8–14 days to encourage the development of multiple eggs, increasing the number available for retrieval and fertilisation.
Fertility blood tests and monitoring
Careful monitoring plays a vital role throughout the stimulation phase. Using a combination of blood tests and ultrasounds, your fertility specialist will closely track how your ovaries are responding and how the follicles (sacs in the ovaries that contain eggs) are developing. These tests allow your specialist to assess if everything is progressing as planned and fine-tune your fertility medication to optimise your results.
As you near the end of the stimulation phase, monitoring is used to determine the optimal time for the ‘trigger injection’, which prepares the eggs for ovulation (i.e. their release from the ovaries). Your fertility nurse will liaise with your fertility specialist and guide you on when to administer the injection, as precise timing is essential – the egg retrieval procedure must occur before natural ovulation. Monitoring usually takes place at one of our Newlife IVF locations in Melbourne. However, you don’t have to be in Melbourne to access treatment. We have patients that live in rural or interstate locations and we work with local pathology and ultrasound providers to assist with our patients’ monitoring needs.
Egg retrieval procedure at our IVF clinic in Melbourne
Egg retrieval, also known as egg collection or egg pickup, is a key step in the IVF process. This procedure involves collecting eggs from your ovaries, which can be frozen for future use or fertilised in the next stage of your IVF cycle.
Performed at our IVF clinic under sedation, egg retrieval is a straightforward procedure that typically takes 20–30 minutes. During this time, your fertility specialist carefully collects eggs from your ovaries using a fine needle guided by ultrasound imaging. On average, 8–12 eggs are retrieved, although the exact number depends on factors such as age, ovarian response to the medication and health history.
Collecting multiple eggs at once is important to IVF success. A higher number of eggs increases the chance of developing the healthy embryos needed for a successful embryo transfer and pregnancy.
Our team understands that undergoing egg retrieval can feel both exciting and a little nerve-wracking. But you can rest assured that we’re here to support you every step of the way so that you feel informed and comfortable throughout the entire IVF process.
Sperm collection and ICSI treatment
On the day of egg retrieval, fresh semen samples are collected from the male partner. If you’re using frozen or donor sperm, our embryologists will ensure the sample is thawed and ready for use.
For standard IVF, the semen sample is carefully prepared by removing the seminal fluid (the fluid that contains sperm), isolating the motile sperm and removing immotile sperm before the insemination procedure
For ICSI, the process is more precise. Only a single sperm is used for fertilisation, requiring experienced embryologists to select the healthiest and most viable sperm and inject it directly into the egg.
Selecting the ideal sperm is a delicate process requiring years of expertise. Our embryologists are trained to identify sperm with the best shape and structure to maximise the chances of successful fertilisation.
Fertilisation and embryo development
The next step in the IVF process is fertilisation, where egg and sperm are brought together.
In some cases, depending on the sperm quality and the patient’s previous history, we use standard insemination, where each egg is placed in a laboratory dish and exposed to thousands of prepared sperm. The fittest sperm may then fertilise the egg naturally, mirroring what would occur in the body.
However, if there are challenges such as low sperm count or abnormalities in sperm quality, an advanced technique called ICSI may be used. With ICSI treatment, a single, healthy-looking sperm is carefully injected into an egg to increase the chances of fertilisation. While this method offers additional precision, it’s important to note that not all eggs will successfully fertilise.
If fertilisation occurs, the resulting embryos are carefully placed in an incubator that mimics the conditions of the female body. Over the next five days, these embryos grow and divide, preparing for the next stage of the IVF process – embryo transfer.
The embryo transfer procedure
The embryo transfer is one of the quickest yet most important stages of the IVF process. During this procedure, a carefully selected embryo is placed into your uterus with the hope that it will successfully implant and lead to pregnancy.
Performed under ultrasound guidance, the transfer involves using a long, thin instrument to gently release the embryo through the vagina and cervix into the uterus. For most women, the procedure feels similar to a routine pap test. It is quick, requires no anaesthetic and allows you to resume your usual activities afterwards.
At Newlife IVF, our fertility specialists and embryologists are committed to providing the highest standard of care and technology to maximise your chances of IVF success.
Pregnancy testing and ongoing support
The pregnancy test represents the culmination of weeks of preparation. This fertility blood test measures the level of human chorionic gonadotrophin (hCG) in your body – a hormone produced when a fertilised egg (an embryo) implants into the uterus. Elevated hCG levels can indicate a successful IVF cycle and the achievement of pregnancy.
This test is performed approximately eleven days after the embryo transfer, giving your body the necessary time to respond to implantation. While waiting for results can be an emotional experience, our dedicated team is here to support you regardless of the outcome.
This webinar, presented by fertility specialists Dr Chris Russell and Dr Nicole Hope, provides a more detailed explanation of the IVF process.
Why choose Newlife IVF?
At Newlife IVF, we understand how significant the IVF process is, and we’re committed to walking beside you on your journey to parenthood. Whether celebrating your success or exploring the next steps, you’ll always have compassionate care and expert guidance from our team.
Clinician-owned and led fertility clinic in Melbourne
As one of few independent specialist fertility centres in Victoria, we take pride in offering a more personalised, compassionate and supportive experience compared to corporate-owned clinics.
State-of-the-art IVF treatment in Melbourne
Every aspect of our practice is thoughtfully designed with your needs in mind, from our expert-led care to our state-of-the-art laboratory and scientific tools and techniques.
Advanced scientific techniques and high IVF success rates
We incorporate cutting-edge scientific advancements into every step of our IVF treatment process, helping to give you the best possible chance of achieving a successful pregnancy.
Our approach includes the use of the EmbryoScope time-lapse system, which provides continuous monitoring of embryo development, sequential media to nurture embryos, and EmbryoGlue to enhance implantation potential when transferring embryos into the uterus.
For ICSI treatment, we take it a step further with egg spindle visualisation technology, allowing us to carefully select eggs with the greatest potential for fertilisation.
Our IVF success rates reflect the effectiveness of these methods, consistently exceeding the national average and giving our patients a better chance of achieving their dream of parenthood.
Accessible and affordable IVF treatment in Melbourne
At Newlife IVF, we believe that everyone deserves the opportunity to build their family, which is why we are committed to providing affordable IVF treatment. Our fee structure is designed to be transparent and accessible, ensuring that fertility treatment, including IVF, is reasonably priced and doesn’t involve the stress of unexpected costs.
Contact Newlife IVF – your trusted fertility clinic in Melbourne
Fertility is largely influenced by the quality of both eggs and sperm. Age is the biggest determinant of egg quality1, but other factors such as diet, weight, physical activity and exposure to toxins (including illicit drugs or medications) also play a role. The good news is that whilst you cannot modify your age, there are things that you can do to improve egg quality and your chances of getting pregnant.
This involves making changes (if needed) to areas of your life that can influence various biological processes in the body – fertility included. With the proper modifications, you can protect your eggs from the harm caused by these factors and increase your likelihood of conceiving.
Why is age such a big factor?
Fertility starts to decline at the beginning of a woman’s 30s, but the decline is more rapid after age 35.1 This is because women are born with a lifetime supply of eggs – around 1-2 million – and this reserve gradually decreases over time. Egg quality also declines with age as the DNA in eggs becomes more susceptible to damage.
Eggs of lower quality are less likely to fertilise and develop into an embryo, affecting the chances of pregnancy. Additionally, older eggs are more likely to be affected by chromosome imbalance, which is associated with difficulty falling pregnant, an increased risk of miscarriage and a higher incidence of children born with a chromosome disorder (e.g. Down Syndrome).2
Unfortunately, once an egg’s DNA is damaged or the egg has an incorrect number of chromosomes (we call this aneuploidy), it cannot be reversed or repaired. For this reason, it’s important to protect your egg quality as much as possible.
Tips to improve your egg quality
Smoking
Women who smoke or are exposed to second-hand smoke often face delays in conceiving. Smoking damages egg DNA, which reduces fertility and increases miscarriage risk.3 It also increases the chance of ectopic pregnancy and makes embryo implantation harder, while increasing the risk of pregnancy complications.4 Therefore, avoiding smoking and second-hand smoke is crucial when trying to conceive and during pregnancy.
Additionally, researchers are still learning about all the risks of e-cigarettes (vapes) on conception and pregnancy. At this stage, no amount of vaping is considered safe when trying to conceive.
Alcohol
If you’re trying to conceive, drinking alcohol can affect your ability to get pregnant and stay pregnant. Some studies suggest that even low to moderate alcohol consumption is associated with reduced fertility.5 Drinking alcohol can alter hormone levels and disrupt the menstrual cycle and the ability to ovulate, therefore reducing the chances of conceiving. So, cutting down or cutting out alcohol can improve your chances of falling pregnant, along with helping you embrace a healthier lifestyle.
Coffee/caffeine
Some studies have shown reduced fertility and increased risk of miscarriage with excessive caffeine consumption.6 Most studies also indicate that the risk of infertility rises with higher levels of caffeine intake. Unfortunately, a safe daily amount of caffeine has not been established. For this reason, we recommend limiting your intake to one caffeinated drink per day (<80–100 mg of caffeine). If you can go without all together, even better!
Illicit drugs
Taking recreational drugs reduces the chances of becoming pregnant and having a healthy baby. For instance, cannabis and opioids are known to disrupt normal hormone production, leading to problems with ovulation and menstrual cycle disturbances.7 Additionally, stimulants such as cocaine and crystal meth have been linked to higher rates of miscarriage.8 Therefore, avoiding illicit drug use is one of the simplest ways to preserve your fertility.
Extreme exercise
Over-exercising can hinder ovulation and hormone production – specifically progesterone production, which is critical in supporting a pregnancy as it helps to thicken the lining of the uterus (needed for embryo implantation). Excessive exercise has also been linked to miscarriage.9 Vigorous exercise should not exceed 4 hours a week. However, lighter activities, such as walking and Pilates, are not limited.
Diet
The Mediterranean diet is often recommended for individuals undergoing in vitro fertilization (IVF) due to its potential benefits for reproductive health – and this may include egg quality. This diet emphasises the consumption of whole foods, including fruits, vegetables, whole grains, legumes, nuts, fish and healthy fats like olive oil, while limiting processed foods, red meat and added sugars.
Research suggests that adherence to the Mediterranean diet may improve fertility outcomes by promoting a healthy weight, reducing inflammation and optimising insulin sensitivity, all of which can positively influence ovarian function and embryo quality.10,11
Maintaining a healthy weight
Being underweight or overweight is associated with reduced pregnancy rates. This is because carrying too little or too much weight can disrupt the balance of hormones in your body, leading to ovulatory issues and irregular periods, along with an increased risk of miscarriage. Even if a woman has a regular cycle, fertility may still be reduced compared to women within the healthy weight range (a body mass index between 18.5 and 25).
Weight loss in overweight people doesn’t have to be drastic to improve fertility. Research has shown that even a modest drop in body weight (5–10%) can increase the chances of pregnancy – not to mention many other health benefits, such as a reduced risk of conditions like diabetes and heart disease, and a lower rate of pregnancy-related complications.12 Weight training and improving your lean body mass is also crucial for optimising your metabolism and reducing insulin resistance.
Weight loss is difficult, but your care providers can help you navigate the weight management journey. Talking to your GP or fertility specialist about weight is a great first step. We’ll make sure you have the support you need.
Medical conditions and medications
Conception is most likely to occur when you’re in good health. Untreated medical conditions, especially hormonal disorders (e.g. thyroid issues) and gynaecological conditions (e.g. endometriosis), can hinder fertility. It’s essential to manage these conditions before trying to conceive. Additionally, ensure that any prescribed medications are safe to take during conception and pregnancy by discussing these with your fertility specialist.
Night shift work
Night shift workers may experience reduced fertility because disrupted or insufficient sleep can interfere with the body’s circadian rhythm, leading to hormonal imbalances. Research on patients undergoing IVF has shown that women working night shifts tend to produce fewer eggs suitable for embryo development.13 Meanwhile, other studies have linked shift work to higher miscarriage rates.14 If possible, avoid night shift work and stick to a regular shift schedule rather than rotating between day and night shifts, as consistency can help reduce the impact on hormone levels.
Supplements for improving egg quality
In addition to lifestyle changes, certain supplements are often recommended. While evidence supporting their impact on egg quality and IVF success rates is limited, some studies suggest potential benefits, whereas others show no significant improvements in fertility outcomes. However, when taken at recommended doses, these supplements are generally considered safe.11
For instance, antioxidants like vitamin E and coenzyme Q10 may enhance IVF outcomes by reducing DNA damage and improving egg quality, particularly in older women or those with diminished ovarian reserve. Other commonly suggested supplements include vitamin D (especially for those with a deficiency) and omega-3 fatty acids.11
Additionally, all women trying to conceive should take a supplement containing at least 400 mcg of folic acid, which is crucial for DNA synthesis and reducing neural tube defects, along with 150 mcg of iodine to support thyroid function.11
Small changes can lead to big results
Simple yet impactful lifestyle changes go a long way towards preserving egg quality, preventing egg damage and improving your overall fertility. By addressing these modifiable factors and prioritising your overall wellbeing, you can boost your chances of conception and a healthy pregnancy.
If you’re ready to explore your options for having a baby or are concerned about your fertility, you can make an appointment with one of our specialists by calling (03) 8080 8933 or by booking online.
References
Better Health Channel. Age and fertility [internet]. Victoria (AU): Better Health Channel; 2023 [updated 2023; cited 2024 Oct]. Available from: https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/age-and-fertility ↩↩
Winship A, Stringer J, Liew S et al. The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing. Hum Reprod Update. 2018;24(2): 19–134. doi: https://doi.org/10.1093/humupd/dmy002. ↩
Pineles BL, Park E, Samet JM. Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol. 2014;179(7):807–23. doi: 10.1093/aje/kwt334. Epub 2014 Feb 10. PMID: 24518810; PMCID: PMC3969532. ↩
Better Health Channel. Pregnancy and smoking [internet]. Victoria (AU): Better Health Channel; 2022 [updated 2022; cited 2024 Oct]. Available from: https://www.betterhealth.vic.gov.au/health/healthyliving/pregnancy-and-smoking ↩
Fan D, Liu L, Xia Q et al. Female alcohol consumption and fecundability: a systematic review and dose-response meta-analysis. Sci Rep. 2017;7(1):13815. doi: https://doi.org/10.1038/s41598-017-14261-8 ↩
Lyngsø J, Ramlau-Hansen CH, Bay B et al. Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose-response meta-analysis. Clin Epidemiol. 2017;9:699–719. doi: 10.2147/CLEP.S146496. PMID: 29276412; PMCID: PMC5733907. ↩
The Society of Obstetricians and Gynaecologists of Canada. Substance use and fertility [internet]. Ontario (CA): The Society of Obstetricians and Gynaecologists of Canada; 2024 [cited 2024 Oct]. Available from: https://www.pregnancyinfo.ca/before-you-conceive/fertility/substance-use-and-fertility/ ↩
Smid MC, Metz TD, Gordon AJ. Stimulant use in Pregnancy: An Under-recognized Epidemic Among Pregnant Women. Clin Obstet Gynecol. 2019;62(1):168–184. doi: 10.1097/GRF.0000000000000418. PMID: 30601144; PMCID: PMC6438363. ↩
Barakat R, Zhang D, Silva-José C et al. The influence of physical activity during pregnancy on miscarriage-systematic review and meta-analysis. J Clin Med. 2023;12(16):5393. doi: 10.3390/jcm12165393. PMID: 37629435; PMCID: PMC10455409. ↩
Hart RJ. Nutritional supplements and IVF: an evidence-based approach. Reprod Biomed Online. 2024;48(3):103770. doi: 10.1016/j.rbmo.2023.103770. ↩
Yang J, Song Y, Gaskins AJ, et al. Mediterranean diet and female reproductive health over lifespan: a systematic review and meta-analysis. Am J Obstet Gynecol. 2023;229(6):617-631. doi: 10.1016/j.ajog.2023.05.030. ↩↩↩↩
Haase CL, Varbo A, Laursen PN et al. Association between body mass index, weight loss and the chance of pregnancy in women with polycystic ovary syndrome and overweight or obesity: a retrospective cohort study in the UK. Hum Reprod. 2023;38(3):471–481. doi: https://doi.org/10.1093/humrep/deac267 ↩
Liu Z, Zheng Y, Wang B et al. The impact of sleep on in-vitro fertilization embryo transfer outcomes: a prospective study. Fertil Steril. 2023;119(1):47–55. doi: 10.1016/j.fertnstert.2022.10.015 ↩
Mínguez-Alarcón L, Souter I, Williams PL, et al. Occupational factors and markers of ovarian reserve and response among women at a fertility centre. Occup Environ Med. 2017;74:426-431. doi: 10.1136/oemed-2016-103953 ↩
Naturopathy takes a holistic approach to your wellbeing and focuses on treatments that support your body to heal itself. A naturopath may recommend a combination of therapies such as herbal remedies, nutritional supplements, and diet and lifestyle advice.
Some evidence suggests that a holistic, naturopathic approach to care can benefit aspects of reproductive health. For example, a study in overweight women with polycystic ovarian syndrome (PCOS) compared the combined effects of herbal supplementation and lifestyle changes with lifestyle changes alone.1 While the combination was not shown to specifically increase conception rates, it did improve other markers of fertility like menstrual cycle regularity (which can support ovulation) and enhanced mental wellbeing scores for depression.1
Herbal remedies
Herbal remedies are commonly used in naturopathy and include plants or parts of a plant – such as roots, flowers, bark, seeds and stems – that are often made into pills, teas or ointments for convenient consumption.
Simple acts like drinking a mug of herbal tea or using moisturisers infused with flower essences can relieve stress and create a sense of inner peace. And specifically regarding gynaecological findings, some herbal therapies have shown benefits. For instance, a study assessing the use of clomiphene (a medication that supports ovulation) combined with black cohosh supplementation in women with subfertility demonstrated increased endometrial thickness and improved hormone profiles.2 Theoretically, this can improve the chances of conception by creating a more receptive uterine environment for embryo implantation.2 However, the study findings did not specifically show an increase in pregnancy rates.2 If you would like to try a herbal remedy, keep in mind that they can affect your fertility treatment medications, so it’s essential to check if a herb is safe with your fertility specialist first.
Acupuncture
Acupuncture is a Chinese medicine practice in which thin needles are inserted into the skin at select acupuncture points. These acupuncture points mark lines of energy flow (called meridians) within the body, and the insertion of acupuncture needles at these points is intended to stimulate this energy flow.
There is limited evidence showing that acupuncture enhances fertility. However, patients may find acupuncture beneficial for stress reduction3 and overall emotional wellbeing.4
Mind-body practices
Mind-body practices are centred on the belief that your mindset can influence your health. Some mind-body practices include mindfulness meditation, yoga, music therapy, hypnosis, art therapy, aromatherapy, guided imagery and cognitive behavioural therapy.
Mindfulness meditation
Mindfulness meditation is a type of meditation that teaches you to become more aware of what you are thinking and feeling. Over time, mindfulness meditation can help you experience each moment with more compassion and less expectation – which may help ease the highs and lows of your fertility journey.
Research has linked mindfulness meditation with fewer difficult emotions, such as depression and stress, and less rumination, which can help you bounce back more easily from the highs and lows of your fertility journey.5
Yoga
Yoga is an ancient Indian mind-body practice that guides you through various postures and stretches. There are multiple styles of yoga, from gentle movements to more physically challenging practices. However, all yoga practices are a form of mindful movement.
The focus on flowing through physical motions and synchronising your movements with your breath can help you reconnect with your body and take a step back from the thoughts passing through your mind. This was evident in a six-week yoga program for women who were waiting for IVF treatment, where yoga was associated with fewer negative thoughts and feelings about fertility and an improved sense of wellbeing.6
Reflexology
Reflexology is a form of massage for the feet, hands and ears, where pressure is applied to select points that are believed to be linked to the function of broader body parts. By applying pressure to these points, reflexology aims to relieve stress and support healing in the body part each point is associated with.
A study comparing reflexology to gentle foot massage in women experiencing infertility found that reflexology did not improve ovulation or pregnancy rates. However, reflexology was associated with lower depression scores, which can help strengthen your resilience and overall fertility treatment experience.7
Take a balanced approach
Current medical research does not directly link complementary remedies to enhanced fertility. However, if such remedies benefit your emotional wellbeing and do not interfere with your current medical treatments, they could be a positive addition.
Always explore these options in consultation with your fertility specialist to ensure that these won’t interfere with your treatment.
There are also other changes you can make to maximise your chances of getting pregnant, such as:
Drinking caffeine in moderation
Incorporating regular movement into your routine
Maintaining a healthy weight
Enjoying a balanced, nutritious diet
Taking the recommended supplements.
If you would like to learn more about lifestyle changes to improve your fertility, you can also read ‘What can I do differently in 2024 to fall pregnant?’ by Newlife IVF fertility specialist Dr Nicole Hope.
Still got questions?
To meet with one of our Newlife IVF fertility specialists and learn more about how you can improve your fertility, you can reach our team by calling (03) 8080 8933 or book online via our appointments page.
References
Arentz S, Smith CA, Abbott J et al. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): A randomized controlled trial. Phytother Res. 2017;31(9):1330-40. doi:10.1002/ptr.5858 ↩↩
Clark N, Will M, Moravek M et al. A systematic review of the evidence for complementary and alternative medicine in infertility. Int J of Gynaecol Obstet. 2013;122(3):202-6. doi: 10.1016/j.ijgo.2013.03.032
HealthProfessional/#:~:text=Today%2C%20black%20cohosh%20is%20most,irritability%20%5B5%2C6%5D ↩↩↩
Xi J, Chen H, Peng ZH et al. Effects of acupuncture on the outcomes of assisted reproductive technology: an overview of systematic reviews. Evid-Based Complement and Alternat Med. 2018;2018:7352735. doi: 10.1155/2018/7352735 ↩
Hassanzadeh Bashtian M, Latifnejad Roudsari R, Sadeghi R. Effects of acupuncture on anxiety in infertile women: a systematic review of the literature. J Midwifery Reprod Health. 2017;5(1):842-8. doi: 10.22038/jmrh.2016.7949 ↩
Patel A, Sharma PSVN, Kumar P. Application of Mindfulness-Based Psychological Interventions in Infertility. J Hum Reprod Sci. 2020;13(1):3-21. doi: 10.4103/jhrs.JHRS_51_19 ↩
Oron G, Allnutt E, Lackman T et al. A prospective study using Hatha Yoga for stress reduction among women waiting for IVF treatment. Reprod Biomed Online. 2015;30(5):542-8. doi: 10.1016/j.rbmo.2015.01.011 ↩
Holt J, Lord J, Acharya U et al. The effectiveness of foot reflexology in inducing ovulation: a sham-controlled randomised trial. Fertil Steril. 2008;91(6):2514-19. doi: https://doi.org/10.1016/j.fertnstert.2008.04.016 ↩
Whether you intend to donate to friends or family, or anonymously, there are several things to consider before you make your decision. Although it can be an incredibly rewarding experience, donating your eggs is a physical and emotional commitment with potentially lifelong implications. It is therefore important to be fully informed before you decide to become a donor.
Things to consider before donating your eggs
Understanding the legal landscape of egg donation in Australia
In Australia, donors have no legal connection to any child conceived as a result of their donation. This means they have no parental responsibilities and are not required to pay child support. Donors also have no legal rights to the child and cannot be granted custody. If you are donating as a known donor, you and the intended parents should discuss how much involvement, if any, you will have in the child’s life. Boundaries should be worked out before you embark on this journey and you may wish to seek legal advice to facilitate this.
If you intend to become an anonymous donor, it’s important to understand that donation is not truly anonymous in Victoria. Children born from your donation can legally request access to your identifying information after they turn 18. This means you may receive contact from them. Additionally, some of your details will be shared with potential recipients – these include eye colour, height, cultural background and health. However, your identity will remain hidden from potential recipients.
Financial considerations – what to expect when donating eggs
In Australia, egg and sperm donation must be altruistic. That is, you cannot receive financial compensation for your donation. However, reasonable expenses can be paid by the recipients, including medical and out-of-pocket costs (such as travel expenses).
Emotional implications of egg donation
Before you donate, you are required to attend mandatory counselling sessions. This is to make sure you fully understand the legal, social and emotional aspects of egg donation. How do you feel about someone else raising a child who is genetically related to you? How will your decision to donate affect your family and children (if you have them)? How do you feel about the potential for future contact with one or more children or adults born as a result of your donation?
At Newlife IVF, our experienced fertility counsellors can help you consider these questions and more. You will complete your counselling feeling fully informed and reassured about your decision and its possible effects on your life in the future.
Physical health and eligibility criteria for egg donors
To become an egg donor, you must be mentally and physically healthy, living a healthy lifestyle, with no family history of inheritable disease. You are also required to be at least 21 years old before you can donate. Ideally, you should be younger than 38 years old. A mandatory health check, including blood tests and ultrasounds, will be performed. You will also be asked lots of questions about your personal and family health history. Once you are given the all-clear, you will be able to donate.
What happens when you donate your eggs
The process of donating your eggs will differ depending on whether you already have frozen eggs available – i.e. from a previous in vitro fertilisation (IVF) cycle – or need to have your eggs collected. Below we discuss both scenarios.
Donating your stored eggs
If you’ve been through IVF and your family is complete, you may have frozen eggs you aren’t intending to use. In this case, you may wish to donate your eggs to an individual or couple who also needs help to have a child. In this case, assuming you fulfil the criteria to become a donor, you will be able to donate your existing frozen eggs.
Egg collection
This process is identical to the first half of an IVF cycle. Before your eggs are collected, you will be given medication to stimulate your ovaries to produce several eggs. This medication comes in the form of a daily injection that will need to be taken for 8 to 14 days. The injection is delivered through a pen device, so it is very easy to use. You can choose to give yourself the injection or ask a friend or family member to do it for you.
Injections will begin on the first day of your period. From around day 5 or 6, a second daily injection will be added, to stop your ovaries from releasing any eggs (ovulating) before they can be collected.
From day 8, you will be monitored using blood tests and ultrasounds to check whether your follicles (small, fluid-filled sacs within the ovaries, each containing a developing egg) are large enough for egg collection. Egg retrieval is usually done at around day 13. About 36 hours prior to collection, the injection that prevents ovulation will be replaced by a so-called ‘trigger injection’. This stimulates the eggs to fully mature before collection.
Egg collection is a day procedure done under light anaesthetic. You won’t be aware of the procedure while it’s happening, nor will you remember it. Egg retrieval is carried out by a fertility specialist, who will use an ultrasound to visualise your ovaries. A thin needle will be inserted through the top of your vagina and into your ovaries to collect the eggs. The procedure takes about 20 minutes, and between 8 and 15 eggs are typically collected.
About 90 minutes after the procedure you will be allowed to go home. After resting at home for 1–2 days, you can resume your normal activities. It is common to experience some abdominal discomfort and bleeding. However, the discomfort is typically fairly mild and manageable with Panadol and a heat pack.
A COVID-19 test is also required prior to the day of the procedure. You will need to isolate at home, separating yourself from others in your household, until the results come back.
After your eggs are collected, an embryologist will look at them under a microscope. If your recipient is ready, they can use the eggs straight away. The mature eggs that are ready for fertilisation will be introduced to sperm on the same day.
If your recipient is not ready, the mature eggs can be frozen until they are ready to be used. They will also be quarantined for a period of 3 months. After the quarantine period has passed, you will be asked to come in for another round of blood tests to double-check that you are healthy. Once you’re given the all-clear, your eggs are ready to be used.
How to donate your eggs
The information in this article is certainly not exhaustive. We recommend that you refer to the information provided by The Health Regulator to gain a more complete understanding of the issues pertaining to egg donation. If you have any additional questions, please do not hesitate to contact us.
If you are ready to take the next step to donate your eggs, book an appointment at Newlife IVF. Whether you want to donate to friends or family, or as an anonymous donor, we can facilitate the process for you. To book your appointment, call (03) 8080 8933 or book online.
Donor sperm – clinic-recruited versus known donors
Essentially, there are two options for obtaining sperm: accessing donor sperm through a fertility clinic’s sperm bank, or using a sample provided by someone you know.
At Newlife IVF we have an on-site sperm bank containing samples recruited from local and international donors. The benefit of using sperm from our clinic-recruited donors is that it is thoroughly tested for infectious diseases and common genetic problems. After we freeze the sperm, it is then quarantined before donors are retested to make sure it is high quality and safe to use.
When you use a clinic-recruited donor, you also have the advantage of very clear legal boundaries. The donor has no legal connection to your child – they are not entitled to custody and do not have to pay child support. They also remain anonymous to a large extent; that is, you will not know the donor’s identity (but you will know their family medical history and some of their traits). However, your child can request that the donor’s identity be revealed to them when they turn 18.
If you choose not to go the clinic-recruited donor route, you may consider using a sperm sample from a friend or acquaintance. A benefit of using a known donor is you will likely have a good understanding of their appearance, background and traits. However, the social and legal boundaries are not as clear-cut as they are when using a clinic-recruited donor. Discussing expectations and creating firm boundaries with a known donor requires careful negotiation, and you may wish to seek legal advice on how best to proceed.
If you do decide to use a sample from someone you know, it’s best to involve a fertility clinic. That way, you can have the sample rigorously tested for safety and quality in the same way we test donor sperm.
In this video, Dr Chris Russell talks about donor sperm and its use in IVF and IUI procedures.
Insemination – how egg and sperm meet
The next consideration is how best to introduce the sperm sample to your egg. There are a few different options for insemination, and the most suitable will depend on your specific circumstances.
One possibility is home insemination. In this method, sperm is injected into the vagina using a syringe at home. As this mimics the natural fertilisation process, home insemination is effective when the donor has a normal sperm count. It is also one of the most cost-effective options. However, it does not afford the same degree of protection from infectious disease as undergoing a similar process via a fertility clinic.
The clinic-based alternative is intrauterine insemination (IUI). This is where a sperm sample is concentrated to contain a very high number of sperm. It is then injected directly into your uterus soon after your ovaries release an egg. Using a concentrated sperm sample increases the chances of a sperm fertilising your egg. Depending on your circumstances, your specialist may recommend combining IUI with a medication to stimulate the release of an egg from your ovaries, further increasing the chance of success.
The last option is in vitro fertilisation (IVF). In this process, several of your eggs will be introduced to sperm in laboratory dishes. When utilising clinic-recruited donor sperm, the best sperm may be selected and a single sperm injected directly into each egg, a process called intracytoplasmic sperm injection (ICSI). One of the best embryos resulting from IVF insemination will then be transferred back to your uterus. The rest can be frozen and stored for later use, if necessary.
In ICSI, a single sperm is injected into the centre of a mature egg.
There are a few reasons you may be advised to undergo IVF. If you have known infertility, you’re in your late 30s or early 40s (when female fertility naturally declines significantly), or you struggle to get pregnant through other forms of insemination, your specialist may recommend this procedure. Likewise, IVF may be advisable if you’re using a known sperm donor with low sperm quality or quantity for other methods of insemination. If you wish to do preimplantation genetic testing, which is the process of genetically testing your embryos before they are transferred to your uterus, IVF will be necessary. For more information about these procedures in relation to your particular circumstances, chat to your fertility specialist.
I’m a single man – what are my options?
To have a baby as a single man, you will need the help of an egg donor and a surrogate. According to Victorian law, these must be two different women.
You may choose to use a clinic-recruited egg donor, or a known donor, i.e. a friend, acquaintance, or a family member (note: the last is only okay if you are not using your own sperm). Egg donation must be altruistic in Australia, meaning no financial compensation is paid for providing eggs. Once the donor eggs are ready, your sperm will be introduced to them using IVF (discussed earlier in this article), and the best resulting embryo will be transferred to your surrogate’s uterus. If you are not using your own sperm, donor embryos may be an appropriate option for you.
It’s common to ask a friend, acquaintance or family member to be a surrogate. Surrogacy is also an altruistic process in Australia, however ‘reasonable’ medical costs can be paid by you. Keep in mind that in Victoria, multiple medical consultations, counselling sessions and legal advice are required for both you and the surrogate prior to proceeding. You will also need to seek permission from the Patient Review Panel (this is a legal requirement in Victoria), and the sperm or embryos must be quarantined. This process can take several months.
Seeking a surrogate overseas may also be an option. However, according to Australian law, this is only legal if it is altruistic. Be aware that this is a very expensive route and you will need to plan to potentially be overseas for a few months after your baby is born to organise their entry into Australia.
For advice related to your particular circumstances, you may wish to seek legal advice and talk to a fertility specialist. Unfortunately, Newlife IVF is not permitted to assist you in finding a surrogate (nor can any other IVF provider). However, our counsellors can certainly orientate you to the Victorian surrogacy community and provide support and information as you look for a potential surrogate.
Ready to have a baby on your own?
Make an appointment with one of our caring and experienced Newlife IVF fertility specialists to discuss the most appropriate way forward based on your medical history, circumstances and preferences. Call (03) 8080 8933 or book online and take the next step towards your dream.
This post was contributed by Laura Oliver, one of Newlife IVF’s counsellors.
Christmas often symbolises a time of joy and happiness. We plan celebratory events with family and friends, and take time to reflect on the end of another year. But this time of year can also be very difficult for women and couples who have been struggling with infertility and going through assisted reproductive treatment (ART) like IVF.
The focus at Christmas time is often on children and families, with Christmas cards and social media posts typically displaying pictures of family events or children with Santa. There can be a real sense of pressure to deliver good news at a time of year when many people are celebrating. However, if you’ve been struggling to fall pregnant or undergoing fertility treatment, the end of the year can serve as a painful marker that you have not achieved what you had hoped for this year, and for some of you, a reminder that yet another 12 months have gone by without a successful outcome.
All of this can bring up unwanted feelings of sadness, frustration, jealousy, anger and grief – and with a barrage of festive mementos and occasions around you to remind you that you’re not pregnant, it’s no wonder you feel this way!
Below are some tips on how you can manage the festive season while coping with fertility issues and undergoing treatment.
Be selective
Pre-plan and be selective about which events you attend at this time of year. If you do attend an event, consider how long to stay there for, and what you can do while there to minimise any feelings of stress or discomfort – for example, helping cook or wash up can help keep you busy and distracted, and may assist you to avoid topics of conversation you don’t want to be involved in.
Warn people in advance that you may find Christmas difficult – this doesn’t mean having to disclose information about your fertility; you can make more general references to having had a stressful or difficult year instead. Try to give your hosts time to understand that this year might look a little different for you, and to not be offended if you decide not to attend or only stay for a short while.
If you have a partner or a support person with you, plan a code word or signal to give when you need them to rescue you from a difficult conversation, or when you want to wind up and go home.
Celebrate
Celebrate how you want. Sometimes, this might feel a little selfish at a time when there are often traditions to uphold or family events to attend, but give yourself permission to celebrate in a way that is comfortable and meaningful to you at this time.
This could mean going away with a friend or just your partner (or staying home) and avoiding big family gatherings. Or starting a new tradition for this time of year. Do something that you know will bring you joy, no matter how small.
Re-charge
Use some of this holiday period to re-charge and take a break from treatment (if you feel you can). Take advantage of your time off work and prioritise self-care – pamper yourself! Get a massage, go away for a few days, plan some day trips to the beach or the countryside, or curl up with a good book.
Reflect
Take some time to reflect on your IVF journey so far, and perhaps think about your plans for treatment moving forward. Is there anything you could do differently next year? What are your expectations, and do you need to adjust these at all? Do you have questions to discuss with your specialist? Perhaps even think about how much longer you think you can continue with IVF treatment before needing to pause and reassess again.
Reflect on your own, with your partner (if you have one) or a support person. You could try using a journal to write down how you’re feeling, record the questions you may have, or come up with a list of pros and cons to aid future decision-making.
Ask for help
Use your supports (partner, family, friends) to help you work through any difficult feelings as they arise. Be open and honest with your networks about how you feel and the ways in which they can be of support to you. Be reassured that the way you are feeling, and the different types of emotions and thoughts that may be triggered at this time of year, are very normal. But we all cope in different ways, so make sure you do whatever it is you need to do to keep your heart, mind and body strong for the year to come. And above all else, remember to be kind to yourself!
Lastly, remember that the Newlife IVF counselling team is here to help. We can help you navigate and unpack your experiences and emotions. If you feel that you could benefit from the support of our counselling team, please call the Newlife IVF team on (03) 8080 8933.
The traditional IVF approach is to allow this meeting to take place ‘naturally’, albeit in a laboratory dish: the woman’s egg is placed in a special culture medium with a prepared semen sample containing thousands of sperm. The fittest sperm fertilises the egg, mimicking what would normally happen in the woman’s reproductive tract.
As its name suggests, ICSI is far more precise. Rather than leaving the egg and sperm to meet of their own accord in a laboratory dish, this technique allows us to directly inject a single sperm into a woman’s egg – thereby, overcoming any issues that may be getting in the way of a sperm and an egg meeting and coming together naturally. Here, we consider some of the reasons why ICSI may be considered during IVF and what specific fertility problems it can help overcome.
Who is ICSI suitable for?
When a couple is experiencing difficulties getting pregnant, it can be easy to focus solely on the woman’s fertility. However, a male factor contributes to infertility in approximately 40% of couples who fail to conceive.1 ‘Male factor infertility’ typically involves an alteration in the number, shape and/or movement of the man’s sperm, all of which can affect the sperm’s ability to fertilise an egg the natural way. ICSI is most commonly used to help overcome these types of sperm-related issues.
ICSI may also sometimes be offered if a woman has very few eggs available (e.g. due to age). In this case, ICSI is used to increase the chances of successful fertilisation, thereby lowering the risk that the woman runs out of eggs before she achieves a successful pregnancy through IVF.
ICSI may also be recommended if one or more previous standard IVF cycles were not successful due to failed fertilisation, or if the reason for cycle failure is unclear but a sperm-related issue is suspected despite a normal semen analysis.2
A checklist for fertile sperm
If your doctor suspects male factor infertility could be affecting your chances of pregnancy, they will usually suggest a semen (sperm) analysis. This is the main method used to test male fertility. During the analysis, a number of different factors that could be affecting your ability to conceive naturally are studied, including:
The volume of semen, which needs to be sufficient to transport sperm into the female reproductive tract
The sperm concentration and total sperm count, which affect the likelihood that enough sperm will reach the egg in order for one to fertilise it
The physical shape of the sperm, as abnormally shaped sperm can have difficulty swimming to the egg or penetrating the egg’s outer layer
The motility of the sperm (i.e. how well it can swim) – if large numbers of sperm in the sample are ‘weak swimmers’, then a natural pregnancy will be more difficult to achieve.
Your specialist might also recommend additional testing for:
Sperm DNA damage or fragmentation: sperm with damaged or fragmented DNA have a reduced chance of fertilising an egg
Sperm antibodies, which if present, can attack and impair sperm function.
Depending on your results, your doctor may then order follow-up tests to make sure the results are accurate and/or to see if anything else is preventing the semen from doing its job.
Once the tests are complete, your specialist will discuss your results with you and explain what your options are, including whether ICSI is likely to increase your chances of successful fertilisation and the overall success of your IVF treatment cycle.
Success rates with ICSI
Because of ICSI, many previously infertile men now have a good chance of fertilising eggs with their sperm. With some couples, pregnancy rates as high as 45% have been achieved with ICSI.3 However, rates this high are not always possible because of other factors, including age and egg quality.
The fertilisation of an egg and its subsequent development into a growing embryo is a complicated process, and there are many reasons why IVF may not be successful, even with the assistance of ICSI. To aid our success rates at Newlife IVF, we:
Ensure an egg is suitable for fertilisation prior to ICSI: Using polarised light microscopy, we assess a structure inside the eggs called a ‘spindle’. We call this ‘egg spindle visualisation’. This allows us to identify if an egg is at a certain stage of development (called metaphase II) and therefore, in optimal condition for fertilisation via ICSI.
Select the healthiest-looking sperm for ICSI: If the genetic information in the sperm has been damaged, or if the sperm is unable to use its DNA correctly, then there is a risk that development of the embryo will fail, even if it has been successfully fertilised via ICSI.4 A number of factors can increase this risk, such as smoking and older age.5,6 It’s not currently possible to know if the sperm we choose for ICSI is completely free of genetic defects. However, by using an advanced imaging system with an extremely high-powered microscope, we are able to study the structure of individual sperm, helping us to select the optimum sperm to inject into an egg. Sometimes, we may also use another technique, called intracytoplasmic morphologically selected sperm injection (IMSI), to help us pick out a healthier sperm based on its shape. A DNA test can also provide us with more details about sperm quality.
Assess the best position to inject the sperm into the egg: Our extremely high-powered microscope also allows us to very precisely inject the selected sperm into the egg, such that we avoid an important structure inside the egg called the spindle. Research has shown that injecting eggs away from the spindle results in higher fertilisation rates and better embryo quality.
Still have questions?
If you are concerned about the possibility of male factor infertility or would like more information about the role of ICSI in an IVF treatment cycle, you can make an appointment with one of our fertility specialists by calling Newlife IVF on (03) 8080 8933. You can also book online via our appointments page.
References
Agerwal A et al. Reprod Biol and Endocrinol. 2015;13:37–46. ↩
Palermo GD et al.Sem Reprod Med. 2015;33:92–102. ↩
Palermo GD et al.Sem Reprod Med. 2009;27:191–201. ↩
Colaco S & Sakkas D. J Assisst Reprod Genet. 2018;35:1953–1968. ↩
García-Ferreyra J et al.Clin Med Insights. Rep Health 2015;9:21–27. ↩
In vitro fertilisation (IVF) is the most widely known fertility treatment, but it is not the only option available to help couples with fertility issues. This is due to the fact that there are many different reasons why an individual or couple may be experiencing fertility problems and treatment should be tailored accordingly. Thus, fertility treatment actually encompasses quite a wide range of methods, each of which can help people to overcome specific challenges and ultimately, conceive. We explain the different options below, including when they might be suitable.
First-line treatments
Ovulation induction
Ovulation induction may be recommended for women who are not ovulating regularly or who are not ovulating at all, and is commonly used for those suffering from polycystic ovarian syndrome (PCOS).
As its name suggests, ovulation induction involves the woman taking medication to increase the level of follicle-stimulating hormone (FSH) that causes ovulation. These medications may be in the form of tablets (clomiphene or letrozole) or direct injections of FSH. This stimulates the growth of ovarian follicles (fluid-filled sacs containing an egg). Once the follicles are large enough, another hormone is then given to release the egg from the follicle. Couples are advised to have intercourse at this time to increase their chances of conceiving.
Intrauterine insemination (IUI)
Intrauterine insemination (also known as artificial insemination) may be considered when a couple has difficulty having intercourse. It may also be appropriate for women with scarring or defects of the cervix that prevent sperm penetration, and for men with mild reductions in either sperm count or sperm motility (i.e. sperm that don’t move properly) where concentrating the semen sample and placing it in the uterus is likely to be of benefit. IUI may be used in combination with medications that stimulate ovulation – this combination can increase the chance of pregnancy in some cases.
During a treatment cycle, patients are monitored closely with blood tests and ultrasounds. At the time of ovulation, sperm are placed directly through the woman’s cervix and into her uterus (womb) using a long, thin plastic tube that is similar to a straw (hence, the name artificial insemination).
Laboratory treatments
In vitro fertilisation (IVF)
IVF is a form of assisted reproductive technology (ART) in which eggs are retrieved from the body of a woman and combined with sperm outside the body to achieve fertilisation. If this is successful and the fertilised egg continues to develop into an embryo, it is transferred back into the uterus (womb) in the hope that it will implant and grow, thereby achieving a pregnancy.
Intracytoplasmic sperm injection (ICSI)
ICSI is a technique where a single sperm is directly injected into an egg to achieve fertilisation. This technique may be recommended when the male partner in a couple has been diagnosed with fertility issues such as low sperm count, abnormal sperm morphology (shape) or motility (movement), has had a previous vasectomy or an unsuccessful vasectomy reversal. The ‘best’ sperm – based on size, shape and movement – is selected for the ICSI procedure.
Sperm retrieval procedures
Some men have no sperm in their semen (a condition known as azoospermia) due to a sperm production problem or a blockage that prevents the sperm from getting into the semen. These men may need to have sperm taken directly from the testis or the epididymis (a coiled tube that stores sperm and transports it from the testis).
Testicular sperm aspiration (TESA) is done by inserting a needle into the testis and taking a small amount of material from the seminiferous tubules – a network of tiny tubes where sperm is produced. The procedure is done using local anaesthesia in an operating theatre.
Percutaneous epididymal sperm aspiration (PESA) can be an option for men who have obstructive azoospermia from a previous vasectomy or infection. Under local anaesthesia, a small needle is inserted into the epididymis to extract sperm. PESA is also usually performed in an operating theatre.
Microdissection TESE (microTESE) may be used for men who have a sperm production problem. This procedure is done under general anaesthetic. The testis is first opened with a small incision, then an operating microscope is used to identify the seminiferous tubules most likely to contain sperm and take tissue samples from them.
Pre-implantation genetic testing (PGT)
PGT is a way to reduce the risk of an individual or a couple passing on a specific genetic or chromosomal abnormality to their child. It may also be used to check for genetic problems in older women (e.g. over the age of 38 years), women who have experienced several miscarriages, or cases of repeated IVF failure.
In PGT, embryos are produced through the usual IVF process and then cells taken from the embryo are tested for genetic conditions. If the embryo is unaffected, it is then transferred to the woman’s uterus.
Egg or sperm freezing
There are two main reasons for freezing eggs. Some women need to freeze their eggs for medical reasons such as impaired ovarian function or impending chemotherapy or radiotherapy for cancer. Other women choose to freeze their eggs because they want to give themselves the option to have children in later years.
A man may be advised to freeze his sperm if he is about to undergo treatment for cancer, or if he has decided to have a vasectomy but may potentially want to have children later on. Men also can freeze sperm prior to either IUI or IVF if they cannot be present on the day scheduled for the respective ART procedure.
Donor treatments
Donor insemination
Donor insemination may be used as part of IVF for a single woman or for women in a same-sex relationship. The process is the same as artificial insemination, but the sperm used is from a donor rather than a male partner.
Donor insemination may be considered when the male partner does not produce sperm (or the sperm is abnormal) or when there is a high risk of the man passing on an illness or abnormality to a child.
Donor eggs
Donor eggs may be an option when a woman is unable to produce eggs or her eggs are of a low quality. This may be due to age or premature ovarian failure (a condition in which a woman stops producing eggs earlier than usual).
Donor eggs may also be appropriate in cases of recurrent miscarriage or if there is a high risk of the woman passing on an illness or abnormality.
Donor embryos
In some cases, some people choose to donate frozen embryos they no longer need. Treatment using these donated embryos may be suitable for a person or a couple who need both donor sperm and donor eggs.
What is the best option for you?
If you would like advice about the next steps to take on your fertility journey, you can make an appointment with one of our fertility specialists by calling Newlife IVF on (03) 8080 8933 or by booking online via our appointments page. We’ll complete a comprehensive assessment before explaining the options available to you and your partner.
Once here, it must ‘implant’ in the wall of the womb and grow before we can say that IVF has resulted in a successful pregnancy. The timing of embryo transfer can vary, depending on whether the embryos being transferred are ‘fresh’ or ‘frozen’. Fresh embryo transfer refers to embryos that are transferred to the uterus 3–5 days after a woman’s eggs have been collected and fertilised by sperm. Frozen embryo transfer refers to embryos that have first been frozen before being thawed at a later date for transfer into the womb.
In the early days of IVF, fresh embryo transfer was the favoured approach. However, the techniques used for freezing and thawing of embryos have since improved to a point where more than 90% of embryos will survive the process. Consequently, a ‘freeze-all’ strategy has become more common, whereby all embryos are frozen following successful growth. They generally remain frozen for at least a month before the best embryos are thawed and transferred into the womb.
Understandably, people undergoing IVF are often eager to get pregnant as quickly as possible – and may assume that fresh embryo transfer is both faster and more effective. But is one approach better than the other?
To appreciate the pros and cons of fresh versus frozen embryo transfer, you first need to understand the so-called ‘window of uterine receptivity’.
The window of uterine receptivity
The success of embryo transfer depends on a number of factors, one of which is uterine receptivity – that is, how ready the uterus is to ‘receive’ the embryo. Outside this window of receptivity, the embryo may fail to implant in the wall of the uterus.
To receive the embryo successfully, the uterus must be ‘primed’ by the hormones oestrogen and progesterone. Under natural conditions, the priming of the uterus is perfectly timed with a woman’s monthly cycle, such that if an egg is released from the ovary and fertilised by sperm, the uterus is ready to receive the embryo. In the IVF setting, however, this timing may be less than perfect.
During IVF, the ovaries are stimulated via self-injectable medication so that the highest possible number of eggs can be collected. By artificially driving the release of so many eggs, the levels of oestrogen and progesterone skyrocket – they can rise to 10 times higher than normal peak levels. This may cause the uterus to prematurely prepare itself for embryo implantation, bringing forward the time frame in which the uterus is receptive. The problem with this is that by the time a fresh embryo is grown and ready for transfer, the window of uterine receptivity may have passed.
Frozen embryo transfer overcomes this problem by delaying the transfer process. This gives the hormone levels time to return to normal and the embryo is then transferred at a later date, when the uterus is receptive again.
When is frozen transfer best?
There are some situations where frozen embryo transfer may be considered the best option, including:
High levels of progesterone: When progesterone levels are high at the time of egg retrieval, there is a higher chance that the window of uterine receptivity will shift forward. In these cases, it is generally better to freeze the embryos and transfer them later when the uterus is receptive again.
Polycystic ovary syndrome (PCOS): Studies have found that women with PCOS tend to have better results from frozen versus fresh transfer. Frozen transfer reduces the risk of ovarian hyperstimulation syndrome (a complication of egg retrieval), and is also associated with a higher chance of ongoing pregnancy.
Embryos that require genetic testing: The genetic testing of embryos takes time. Consequently, by the time a tested embryo is ready for transfer, the window of uterine receptivity is likely to be over. In this scenario, frozen embryo transfer is usually more appropriate.
What are the arguments for fresh transfer?
On the other side of the coin, fresh transfer avoids the need for the freeze-thaw process. While current technology enables a greater than 90% survival rate for frozen embryos, this level of risk may not be acceptable for some patients – especially if they already have a low number of embryos. Fresh transfer potentially also results in a shorter time to pregnancy.
Which is the best option for you?
When choosing between fresh and frozen embryo transfer, there is no one-size-fits-all approach. As with all aspects of fertility care, the decisions need to be personalised to your individual circumstances. Our fertility specialists will assess the specifics of your situation and tailor their advice accordingly.
If you would like professional advice about the next steps to take on your fertility journey, you can make an appointment with one of our fertility specialists by calling Newlife IVF on (03) 8080 8933. Alternatively, you can book online via our appointments page.
What is IVF and how does it work?
In ICSI, a single sperm is injected into the centre of a mature egg.